AN UPDATE ON HBED: A POTENTIALLY USEFUL ORAL IRON CHELATOR.† 916
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چکیده
منابع مشابه
Oral iron chelator L1 and autoimmunity.
As Brittenham’ has reviewed in detail, the use of the oral iron chelator LI has been associated with significant clinical and animal toxicity. One of the more controversial issues surrounding the human use of LI has been the possible development of autoimmune phenomena as manifested by development of autoantibodies such as antinuclear antibodies (ANA). The Canadian group investigating LI did no...
متن کاملDeferasirox: a novel, once-daily oral iron chelator
10.1586/14750708.3.4.453 © 2 Regular blood transfusions for the treatment of chronic anemia inevitably lead to iron overload since humans do not possess a physiological mechanism for removing excess iron. Without appropriate treatment, the cumulative effects of iron overload lead to severe organ damage and, ultimately, death. The iron chelating agent, deferoxamine, has been used effectively for...
متن کاملExjade (ICL 670): A new oral iron chelator.
ICL670(deferasirox) is a tridentate oral iron chelator that has shown high efficacy and theraputic safety in preclinical and currently ongoing phase III clinical evaluation. The drug has been just approved by US FDA for use in iron-loading anaemias. It is an ideal once-daily oral chelator, the effective dose of which is between 20 and 40 mg/kg. Iron is chelated & excreted almost exclusively via...
متن کاملEffects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma
AIM To evaluate the inhibitory effects of deferasirox (DFX) against hepatocellular carcinoma (HCC) through basic and clinical studies. METHODS In the basic study, the effect of DFX was investigated in three hepatoma cell lines (HepG2, Hep3B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy w...
متن کاملThe effect of desferrithiocin, an oral iron chelator, on T-cell function.
Desferrithiocin is a new, potent, orally available iron chelator. To determine whether this drug might be useful not only for iron-overload but also for immunosuppression, we studied the in vitro effects of desferrithiocin on T-lymphocyte function. Like deferoxamine, desferrithiocin inhibited, in a dose-dependent fashion, mitogen- and lectin-induced proliferation of both human and murine T cell...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00938